Talk:Ursodeoxycholic acid

Untitled

Would plant sterols have a similiar effect as it blocks the absorbtion of cholestorol?Interestedperson (talk) 14:38, 22 January 2009 (UTC)

Medical uses

This section reads terribly, just random bits of info about lack of evidence. Please could somebody who knows about this write a list of what it's currently used for; you can keep the info about the lack of evidence. Edit: Just added a list of some that I knew, with some sources to their use. Feel free to add more.

Expensive? Not so much...

Article says "The drug is very expensive". I am not sure when this was written or in what country it's referring to, but I just checked the wholesale cost, and one of the major US pharmacy wholesalers is charging $22.75 for 100 capsules (300mg) as of today. This seems eminently reasonable to me. If anyone wants to justify leaving this sentence in, have at it; otherwise I'm removing it in a week. Shalom S. (talk) 21:30, 2 May 2012 (UTC)

In Australia it is heavily subsidised by the Australian Government and can be purchased retail on special authority prescription (you have to be very ill) for AU$33 for 200 capsules. Otherwise it retails for AU$250 per 100. That makes it expensive. (At time of writing US$1.00 = AU$0.97) — Preceding unsigned comment added by 124.171.87.7 (talk) 09:40, 6 July 2012 (UTC)

What are the current prices for UDCA and TUDCA, for example in USA and in Europe?

TUDCA is here: https://en.wikipedia.org/wiki/Ursodoxicoltaurine

--91.159.189.212 (talk) 15:38, 10 June 2023 (UTC)

Interpretation of Study

I just revised the section that previously stated that the use of this drug is associated with hepatocellular carcinoma (HCC, i.e. primary liver cancer) in those with Primary Biliary Cirrhosis (PBC) who don't respond to the drug, at an incidence of 20% after 15 years. This is not what the study (http://www.ncbi.nlm.nih.gov/pubmed/21389798) says.

All of the patients in the study had PBC. All of them were treated with the drug. The disease's natural course is to lead to cirrhosis, which, in turn, can lead to HCC. The drug is FDA-approved to slow the progression of the disease, but not everyone responds. Those who don't respond to the drug, by definition, experience the progression of the disease more quickly, and therefore experience a higher incidence of HCC. There's no evidence that the use of the drug itself was associated with HCC. For example, there was no control group of PBC-free patients who also took the drug. As previously written, then, the claim invited the inference that PBC patients who are non-responsive to the drug can reduce their HCC risk by simply discontinuing the drug, which is not at all what the study says. Hopefully the clarified text is more helpful. — Preceding unsigned comment added by 70.174.135.194 (talk) 22:10, 18 October 2014 (UTC)

Possible copyright problem

This article has been revised as part of a large-scale clean-up project of multiple article copyright infringement. (See the investigation subpage) Earlier text must not be restored, unless it can be verified to be free of infringement. For legal reasons, Wikipedia cannot accept copyrighted text or images borrowed from other web sites or printed material; such additions must be deleted. Contributors may use sources as a source of information, but not as a source of sentences or phrases. Accordingly, the material may be rewritten, but only if it does not infringe on the copyright of the original or plagiarize from that source. Please see our guideline on non-free text for how to properly implement limited quotations of copyrighted text. Wikipedia takes copyright violations very seriously. Moneytrees🌴^{Talk🌲Help out at CCI!} 21:52, 29 April 2020 (UTC)

Note that this seems to be a good edit and can be re-inserted. Moneytrees🌴^{Talk🌲Help out at CCI!} 21:52, 29 April 2020 (UTC)

I have reinserted many of the edits I did after this disruption. Further review will help! Jrfw51 (talk) 17:41, 30 April 2020 (UTC)

SARS-CoV-2 infection

Reference: “FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2” by Teresa Brevini, et al. From https://pubmed.ncbi.nlm.nih.gov/36470304/

Researchers have found that, " ...ursodeoxycholic acid (UDCA), an off-patent drug used to treat a form of liver disease known as primary biliary cholangitis...." may be a new way to prevent all variants of covid-19 infections in certain populations. 99.115.154.2 (talk) 05:57, 30 December 2022 (UTC)

Does it work also against other common respiratory viruses? Or any other viruses we humans often may catch?

91.159.189.212 (talk) 15:40, 10 June 2023 (UTC)

Does also TUDCA work in covid-19 treatment? TUDCA is available as dietary supplement, UDCA is available as cheap generic prescription drug, but the difficult thing is prescription may be required in all countries to use UDCA?

https://en.wikipedia.org/wiki/Talk:Ursodoxicoltaurine#If_UDCA_works_for_covid-19_treatment,_does_TUDCA_work_also?

91.159.186.9 (talk) 11:35, 31 July 2023 (UTC)

Supresses immune response?

Wikipedia now says:

Ursodeoxycholic acid has also been shown experimentally to suppress immune response such as immune cell phagocytosis. Prolonged exposure and/or increased quantities of systemic (throughout the body, not just in the digestive system) ursodeoxycholic acid can be toxic. Source: https://fscimage.fishersci.com/msds/70916.htm

I found NONE of the bolded claims from this source.

For example this source says:

"Potential Health Effects Chronic: No information found.

California Prop 65 California No Significant Risk Level: None of the chemicals in this product are listed".

Are these side-effects possible for people who take Ursodeoxycholic acid as prescription medicine?

Or only for people who work at a factory that handles pure 99% Ursodeoxycholic acid?

91.159.186.9 (talk) 11:32, 31 July 2023 (UTC)